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Anesthesiology
Dr Julie Freed, MD, PhD

Julie Freed, MD, PhD

Associate Professor; Executive Vice Chair; Director of Clinical Research

Contact Information

Education

BA, Physiology, University of Minnesota, 2002
PhD, Physiology, 老澳门六合彩图库, 2008
MD, 老澳门六合彩图库, 2011
Residency, Anesthesiology, 老澳门六合彩图库, 2016
Fellowship, Cardiac Anesthesiology, 老澳门六合彩图库, 2017

Research Experience

  • Adult
  • Arterioles
  • Coronary Vessels
  • Endothelial Cells
  • Endothelium, Vascular
  • Humans
  • Microcirculation
  • Nitric Oxide

Clinical Expertise

  • Anesthesia, Cardiac Procedures
  • Echocardiography, Transesophageal

Leadership Positions

  • Director of Clinical Research, Department of Anesthesiology

Research Interests

  • Human coronary microvascular dysfunction
  • The role of sphingolipids in vascular function
  • Mechanisms and treatments of vasoplegia
  • Surgical prehabilitation in frail patients

Dr. Freed’s research primarily focuses on the role that sphingolipids have in the development of endothelial dysfunction in the human microcirculation. Elevated plasma levels of ceramide, a prototypical sphingolipid, is now considered an independent risk factor for major adverse cardiovascular events in otherwise healthy people. The Freed lab is currently investigating how these bioactive lipids are regulated in human endothelial cells.

As a cardiac anesthesiologist, Dr. Freed is also interested in intraoperative blood pressure control including mechanisms and treatments of vasoplegia. Other interests include translating her work in the lab to improve outcomes for surgical patients.

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Publications

  • (SenthilKumar G, Katunaric B, Zirgibel Z, Lindemer B, Jaramillo-Torres MJ, Bordas-Murphy H, Schulz ME, Pearson PJ, Freed JK.) Circ Res. 2024 Jan 05;134(1):81-96 PMID: 38037825 PMCID: PMC10766100 SCOPUS ID: 2-s2.0-85181767221 12/01/2023

  • (SenthilKumar G, Mathieu NM, Freed JK, Sigmund CD, Gutterman DD.) Am J Physiol Heart Circ Physiol. 2023 Oct 01;325(4):H882-H887 PMID: 37624099 SCOPUS ID: 2-s2.0-85171900302 08/25/2023

  • (SenthilKumar G, Katunaric B, Bordas-Murphy H, Sarvaideo J, Freed JK.) Endocrinology. 2023 Apr 17;164(6) PMID: 37207450 PMCID: PMC10230790 SCOPUS ID: 2-s2.0-85163898622 05/20/2023

  • (SenthilKumar G, Katunaric B, Bordas-Murphy H, Young M, Doren EL, Schulz ME, Widlansky ME, Freed JK.) Am J Physiol Heart Circ Physiol. 2023 Mar 01;324(3):H330-H337 PMID: 36607795 PMCID: PMC9925162 SCOPUS ID: 2-s2.0-85147536237 01/07/2023

  • (Patel JJ, Willoughby R, Peterson J, Carver T, Zelten J, Markiewicz A, Spiegelhoff K, Hipp LA, Canales B, Szabo A, Heyland DK, Stoppe C, Zielonka J, Freed JK.) Chest. 2023 Feb;163(2):303-312 PMID: 36174744 SCOPUS ID: 2-s2.0-85146132356 09/30/2022

  • (SenthilKumar G, Gutierrez-Huerta CA, Freed JK, Beyer AM, Fancher IS, LeBlanc AJ.) Am J Physiol Heart Circ Physiol. 2022 Dec 01;323(6):H1167-H1175 PMID: 36306213 PMCID: PMC9678417 SCOPUS ID: 2-s2.0-85142403599 10/29/2022

  • (Katunaric B, SenthilKumar G, Schulz ME, De Oliveira N, Freed JK.) Hypertension. 2022 Oct;79(10):2250-2261 PMID: 36070401 PMCID: PMC9473289 SCOPUS ID: 2-s2.0-85137486054 09/08/2022

  • (Boettcher BT, Woehlck HJ, Makker H, Pagel PS, Freed JK.) Int J Surg Case Rep. 2022 Sep;98:107488 PMID: 35981485 PMCID: PMC9399471 SCOPUS ID: 2-s2.0-85135893802 08/19/2022

  • (Joyce DL, Lynch BE, Freed J, Kreuziger LB, Salinger MH, Joyce LD.) Artif Organs. 2022 Apr;46(4):705-709 PMID: 35080023 SCOPUS ID: 2-s2.0-85124909222 01/27/2022

  • (Cohen KE, Katunaric B, Schulz ME, SenthilKumar G, Young MS, Mace JE, Freed JK.) Front Pharmacol. 2022;13:875900 PMID: 35444544 PMCID: PMC9014203 SCOPUS ID: 2-s2.0-85128486794 04/22/2022

  • (Cohen KE, Katunaric B, SenthilKumar G, McIntosh JJ, Freed JK.) Am J Physiol Heart Circ Physiol. 2022 Jan 01;322(1):H57-H65 PMID: 34797171 PMCID: PMC8698498 SCOPUS ID: 2-s2.0-85122249089 11/20/2021

  • (Gaulton TG, Neuman MD, US intubateCOVID Investigators.) Br J Anaesth. 2021 May;126(5):e184-e186 PMID: 33612248 PMCID: PMC8052559 SCOPUS ID: 2-s2.0-85104297993 02/23/2021

Publications of from the

Lab Members

  • Laura Norwood PhD, Research Scientist
  • Mary Schulz, Research Technician
  • Kelsey Walters, Medical Student

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