Lu Han, PhD
Assistant Professor
Locations
- The Herma Heart Institute, Children鈥檚 Wisconsin
8701 Watertown Plank Rd.
TBRC/CRI, 2nd Floor, C2475
Contact Information
General Interests
Education
PhD, Institute of Biophysics, Chinese Academy of Sciences - Beijing China, 2010
BS, Jilin University - Changchun China, 2003
Honors and Awards
Award for Randall Big Idea Competition, Pittsburgh, PA
Travel Award for Weinstein Conference, Boston, MA
Research Areas of Interest
- Cardiology
- Cell Differentiation
- Induced Pluripotent Stem Cells
- Mitosis
- Myocytes, Cardiac
Research Interests
Heart disease is the leading cause of mortality and morbidity worldwide. One of the fundamental problems is that unlike other organs, once injured the adult human heart cannot heal itself due to the minimal proliferative capacity within heart muscle cells (cardiomyocytes). Despite significant efforts invested in developing new strategies, a clinically effective approach for the treatment of an injured adult human heart does not exist. This highlights the need to understand fundamental mechanisms regulating heart repair and how to control them.
The research interests of the Han lab reside at the interface of Cell Biology, Genomics, and Cardiology. We employ several experimental systems, including engineered mouse models and human-induced pluripotent stem cells, to understanding the regulation and consequences of cardiomyocyte terminal differentiation, both during heart development and in response to different forms of pathological insults. In addition, we utilize a variety of molecular and computational techniques to dissect the diversity of cellular behavior via single-cell functional genomics.
Our research will help to answer three major questions related to human heart repair: (1) Does a subpopulation of human cardiomyocytes possess a proliferative potential? If so, is it caused by ploidy composition and how can it be controlled?; (2) What role does polyploid cardiomyocytes play in cardiac growth and repair? and; (3) How to induce human iPSC maturation in-vitro with further comprehension of the mechanisms directing cardiomyocyte terminal differentiation?
Ultimately, we will provide a cell biology view to better understand human heart disease and develop regenerative strategies.
Publications
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(Auchampach J, Han L, Huang GN, Kühn B, Lough JW, O'Meara CC, Payumo AY, Rosenthal NA, Sucov HM, Yutzey KE, Patterson M.) Am J Physiol Heart Circ Physiol. 2022 Apr 01;322(4):H579-H596 PMID: 35179974 PMCID: PMC8934681 SCOPUS ID: 2-s2.0-85127729067 02/19/2022
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(Kirillova A, Han L, Liu H, Kühn B.) Development. 2021 Jul 15;148(14) PMID: 34897388 PMCID: PMC8326922 12/14/2021
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(Han L, Mich-Basso J, Kühn B.) Methods Mol Biol. 2021;2158:125-139 PMID: 32857370 PMCID: PMC8221246 08/29/2020
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(Han L, Choudhury S, Mich-Basso JD, Ammanamanchi N, Ganapathy B, Suresh S, Khaladkar M, Singh J, Maehr R, Zuppo DA, Kim J, Eberwine JH, Wyman SK, Wu YL, Kühn B.) Dev Cell. 2020 Apr 06;53(1):42-59.e11 PMID: 32109383 PMCID: PMC7346764 02/29/2020
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(Liu H, Zhang CH, Ammanamanchi N, Suresh S, Lewarchik C, Rao K, Uys GM, Han L, Abrial M, Yimlamai D, Ganapathy B, Guillermier C, Chen N, Khaladkar M, Spaethling J, Eberwine JH, Kim J, Walsh S, Choudhury S, Little K, Francis K, Sharma M, Viegas M, Bais A, Kostka D, Ding J, Bar-Joseph Z, Wu Y, Yechoor V, Moulik M, Johnson J, Weinberg J, Reyes-Múgica M, Steinhauser ML, Kühn B.) Sci Transl Med. 2019 Oct 09;11(513) PMID: 31597755 PMCID: PMC8132604 10/11/2019
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(Lin B, Li Y, Han L, Kaplan AD, Ao Y, Kalra S, Bett GC, Rasmusson RL, Denning C, Yang L.) Dis Model Mech. 2015 May;8(5):457-66 PMID: 25791035 PMCID: PMC4415895 03/21/2015
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(Han L, Li Y, Tchao J, Kaplan AD, Lin B, Li Y, Mich-Basso J, Lis A, Hassan N, London B, Bett GC, Tobita K, Rasmusson RL, Yang L.) Cardiovasc Res. 2015 Apr 01;106(1):6-7 PMID: 25691542 02/19/2015
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(Han L, Li Y, Tchao J, Kaplan AD, Lin B, Li Y, Mich-Basso J, Lis A, Hassan N, London B, Bett GC, Tobita K, Rasmusson RL, Yang L.) Cardiovasc Res. 2014 Nov 01;104(2):258-69 PMID: 25209314 PMCID: PMC4217687 09/12/2014
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(Tchao J, Han L, Lin B, Yang L, Tobita K.) Sci Rep. 2014 Oct 14;4:6614 PMID: 25310989 PMCID: PMC4196107 10/15/2014
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(Lu TY, Lin B, Li Y, Arora A, Han L, Cui C, Coronnello C, Sheng Y, Benos PV, Yang L.) J Mol Cell Cardiol. 2013 Oct;63:146-54 PMID: 23939491 PMCID: PMC4268488 08/14/2013
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(Cui P, Lin Q, Xin C, Han L, An L, Wang Y, Hu Z, Ding F, Zhang L, Hu S, Hang H, Yu J.) Carcinogenesis. 2010 Sep;31(9):1661-8 PMID: 20513671 SCOPUS ID: 2-s2.0-77956283059 06/02/2010
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(Han L, Hu Z, Liu Y, Wang X, Hopkins KM, Lieberman HB, Hang H.) Mol Cancer. 2010 Mar 24;9:67 PMID: 20334655 PMCID: PMC2864214 SCOPUS ID: 2-s2.0-77952656146 03/26/2010