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Research Group Lab Hall
Pharmacology and Toxicology

Gilbert C. White, II, MD

Executive Vice President for Research and Director, Versiti Blood Research Institute; Richard H. and Sara E. Aster Chair for Medical Research, Blood Center of Wisconsin; Professor, Medicine and Biochemistry; Associate Dean for Research, 老澳门六合彩图库

Locations

  • Versiti 230

Contact Information

Research Experience

  • 1-Alkyl-2-acetylglycerophosphocholine Esterase
  • Antigens, Human Platelet
  • Aspirin
  • Bernard-Soulier Syndrome
  • beta-Thromboglobulin
  • Blood Coagulation Disorders
  • Blood Platelet Disorders
  • Blood Platelets
  • Clot Retraction
  • Disintegrins
  • Factor IX
  • HELLP Syndrome

Research Interests

The overall goal of the White lab is to understand the signaling pathways that mediate the hemostatic responses of blood platelets. Understanding these responses at a molecular level permits the development of methods to selectively and precisely manipulate those pathways, thereby controlling vascular diseases like heart attacks and strokes. A current focus is the role of rap1b, a low molecular weight GTP binding protein member of the ras superfamily, which is present in high concentrations in platelets and plays a role in the activation in platelets, including platelet aggregation, the integrin-mediated interaction of one platelet with another to form a platelet hemostatic plug. Rap1b also plays a role in the inhibition of platelets by cyclic AMP. Thus, rap1b appears to be positioned as a unique and critical bi-directional modulator of platelet activation. Using knock-out and transgenic mice combined with proteomic and genetic approaches like yeast two-hybrid screening, we are exploring the pathway(s) by which rap1b and other proteins mediate signals from G-protein coupled receptors such as P2Y12 to integrins like aIIbb3 that mediate platelet aggregation. We are also exploring the pathway(s) that link cyclic AMP and rap1b. Understanding the rap1b-dependent pathways that are involved in mediating platelet responses will provide new ways to control platelet in vascular diseases.

Publications

  • (Xu Z, Ni B, Cao Z, Zielonka J, Gao J, Chen F, Kalyanaraman B, White GC, Ma YQ.) J Leukoc Biol. 2018 Sep;104(3):597-602 PMID: 29656482 PMCID: PMC6113072 SCOPUS ID: 2-s2.0-85045414281 04/16/2018

  • (Brackmann HH, White GC 2nd, Berntorp E, Andersen T, Escuriola-Ettingshausen C.) Haemophilia. 2018 Apr;24 Suppl 3:3-14 PMID: 29543371 SCOPUS ID: 2-s2.0-85044034021 03/16/2018

  • (White GC 2nd, Blatt PM.) J Thromb Haemost. 2017 Dec;15(12):2468-2470 PMID: 29152851 SCOPUS ID: 2-s2.0-85034226094 11/21/2017

  • (Gao J, Huang M, Lai J, Mao K, Sun P, Cao Z, Hu Y, Zhang Y, Schulte ML, Jin C, Wang J, White GC, Xu Z, Ma YQ.) J Cell Sci. 2017 Nov 01;130(21):3764-3775 PMID: 28954813 PMCID: PMC6040092 SCOPUS ID: 2-s2.0-85032841608 09/29/2017

  • (Key NS, Khorana AA, Mackman N, McCarty OJ, White GC, Francis CW, McCrae KR, Palumbo JS, Raskob GE, Chan AT, Sood AK.) Cancer Res. 2016 Jul 01;76(13):3671-5 PMID: 27527638 SCOPUS ID: 2-s2.0-84977522286 08/17/2016

  • (Xu Z, Cai J, Gao J, White GC 2nd, Chen F, Ma YQ.) Blood. 2015 Jul 16;126(3):373-7 PMID: 26056166 SCOPUS ID: 2-s2.0-84937808554 06/10/2015

  • (White GC 2nd, Francis CW.) J Thromb Haemost. 2015 Jul;13(7):1354-7 PMID: 26095865 SCOPUS ID: 2-s2.0-85028268876 06/23/2015

  • (Chrzanowska-Wodnicka M, White GC 2nd, Quilliam LA, Whitehead KJ.) PLoS One. 2015;10(12):e0145689 PMID: 26714318 PMCID: PMC4694701 SCOPUS ID: 2-s2.0-84958225316 12/30/2015

  • (Ferraris VA, Boral LI, Cohen AJ, Smyth SS, White GC 2nd.) Cardiol Rev. 2015;23(2):53-68 PMID: 25436468 PMCID: PMC4323575 SCOPUS ID: 2-s2.0-84922824715 12/02/2014

  • (Xu Z, Chen X, Zhi H, Gao J, Bialkowska K, Byzova TV, Pluskota E, White GC 2nd, Liu J, Plow EF, Ma YQ.) Arterioscler Thromb Vasc Biol. 2014 Sep;34(9):1961-7 PMID: 24969775 PMCID: PMC4167429 SCOPUS ID: 2-s2.0-84906939916 06/28/2014

  • (Blatt PM, White GC 2nd.) J Thromb Haemost. 2014 Apr;12(4):574 PMID: 24345100 SCOPUS ID: 2-s2.0-84898053112 12/19/2013

  • (Zheng Y, Wang AW, Yu M, Padmanabhan A, Tourdot BE, Newman DK, White GC, Aster RH, Wen R, Wang D.) Blood. 2014 Feb 06;123(6):931-4 PMID: 24357731 PMCID: PMC3916881 SCOPUS ID: 2-s2.0-84897574667 12/21/2013

Publications of from the

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