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Asthma/Allergy and Clinical Immunology

老澳门六合彩图库 Asthma/Allergy and Clinical Immunology Research Programs

The Division of Asthma, Allergy, and Immunology has a robust clinical trial portfolio. Clinical trials include studies related to Asthma, Hereditary Angioedema (HAE), Hypereosinophilic Syndrome (HES) and Primary Immunodeficiency. In addition, the Division also has funded asthma and primary immunodeficiency disease research.

Current Research Studies

Pediatric and Adult Asthma Trials

Pediatric and Adult Asthma Trials

  • Phase IIIb Multi-center, Randomized, Double¬-Blind, Placebo-¬Controlled Study of Xolair® in Subjects with Moderate to Severe Persistent Asthma Who are Inadequately Controlled With High-Dose Inhaled Corticosteroids and Long-Acting Beta-Agonist
  • Epidemiologic Study of Xolair® (Omalizumab): Evaluating Clinical Effectiveness and Long-Term Safety in Patients With Moderate to Severe Asthma (EXCELS)
  • A 1 Year, Randomized, Double Blind, Parallel-Group, Placebo-Controlled, Multicenter Evaluation of Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of Omalizumab in Children (6 - <12 years) With Moderate-Severe, Persistent, Inadequately Controlled Allergic Asthma.
  • Study of Acid Reflux in Children with Asthma (SARCA): The purpose of this NIH funded research is to test the hypothesis that children with symptomatic asthma will have improved asthma control with medical treatment of esophageal reflux with the proton-pump inhibitor, lansoprazole, as compared to children treated with placebo.
Food Allergy

Food Allergy

We have ongoing clinical research projects in the area of food allergies. Current studies include:

  • Detection of Peanut Protein in Serum and Saliva
  • Determination Of Minimum And Non-Provoking Doses Of Soy Protein In Soy Allergic Individuals
Primary Immunodeficiency

Primary Immunodeficiency

  • Pilot Program to Screen Newborns for Severe Combined Immune Deficiency (SCID) in Wisconsin: The purpose of this research is to develop a collaborative program with the WI State Department of Hygiene to screen all newborns in the State of WI for SCID. We will extract DNA from blood spots on newborn screening cards and use real time PCR to quantitate T cell receptor circles to screen for SCID.
  • Lymphoproliferative Disorders in Primary Immunodeficiencies: the purpose of this research is to determine if transforming viral infections lead to lymphoproliferative disorders in patients with primary immune deficiencies.

Recent Department Publications

  • (Totka JP, Peña M, Steinberg JA, Wolfgram PM.) J Pediatr Health Care. 2024 Dec 06 PMID: 39652044 12/09/2024

  • (Conner JE, Steinberg JA.) Med Clin North Am. 2024 Jan;108(1):123-155 PMID: 37951646 SCOPUS ID: 2-s2.0-85165235635 11/12/2023

  • (Zafra H, Chiu AM.) Ann Allergy Asthma Immunol. 2023 Sep;131(3):298-299 PMID: 37169326 SCOPUS ID: 2-s2.0-85160438067 05/12/2023

  • (Bashir A, Cabrera JM, Suchi M, Pelz BJ.) JPGN Rep. 2023 Aug;4(3):e320 PMID: 37600609 PMCID: PMC10435027 08/21/2023

  • (Louis R, Harrison TW, Chanez P, Menzella F, Philteos G, Cosio BG, Lugogo NL, de Luiz G, Burden A, Adlington T, Keeling N, Kwiatek J, Garcia Gil E, ANDHI Study Investigators.) J Allergy Clin Immunol Pract. 2023 Jun;11(6):1759-1770.e7 PMID: 36948488 SCOPUS ID: 2-s2.0-85152514359 03/23/2023

  • (Chovanec J, Tunc I, Hughes J, Halstead J, Mateja A, Liu Y, O'Connell MP, Kim J, Park YH, Wang Q, Le Q, Pirooznia M, Trivedi NN, Bai Y, Yin Y, Hsu AP, McElwee J, Lassiter S, Nelson C, Bandoh J, DiMaggio T, 艩elb J, Rijavec M, Carter MC, Komarow HD, Sabato V, Steinberg J, Hafer KM, Feuille E, Hourigan CS, Lack J, Khoury P, Maric I, Zanotti R, Bonadonna P, Schwartz LB, Milner JD, Glover SC, Ebo DG, Koro拧ec P, Caughey GH, Brittain EH, Busby B, Metcalfe DD, Lyons JJ.) Blood Adv. 2023 May 09;7(9):1796-1810 PMID: 36170795 PMCID: PMC10164828 SCOPUS ID: 2-s2.0-85160092678 09/29/2022

  • (Jones D, Zafra H, Anderson J.) Journal of Asthma and Allergy. 2023;16:447-460 SCOPUS ID: 2-s2.0-85158155205 01/01/2023

  • (Nelson A, Singh A, Dasgupta M, Simpson PM, Chiu A, Brousseau DC, Panepinto JA.) J Asthma. 2022 Oct;59(10):1981-1988 PMID: 34570989 PMCID: PMC9001749 SCOPUS ID: 2-s2.0-85117257537 09/28/2021

  • (Rembalski S, Steinberg JA.) J Immunother. 2022 Oct 01;45(8):370-373 PMID: 35913799 SCOPUS ID: 2-s2.0-85137746066 08/02/2022

  • (Chou EY, Pelz BJ, Chiu AM, Soung PJ.) Crit Care Clin. 2022 Apr;38(2):213-229 PMID: 35369944 SCOPUS ID: 2-s2.0-85127335877 04/05/2022

  • (Zafra H.) WMJ. 2022 Apr;121(1):48-53 PMID: 35442579 SCOPUS ID: 2-s2.0-85128793938 04/21/2022

  • (Lee GB, Chiu AM.) Ann Allergy Asthma Immunol. 2022 Mar;128(3):256-262 PMID: 34929390 SCOPUS ID: 2-s2.0-85122299266 12/21/2021

  • (Gaberino CL, Chiu AM, Mahatme SS.) Ann Allergy Asthma Immunol. 2022 Mar;128(3):307-313 PMID: 34890777 SCOPUS ID: 2-s2.0-85122084422 12/11/2021

  • (Banerji A, Bernstein JA, Johnston DT, Lumry WR, Magerl M, Maurer M, Martinez-Saguer I, Zanichelli A, Hao J, Inhaber N, Yu M, Riedl MA, HELP OLE Investigators.) Allergy. 2022 Mar;77(3):979-990 PMID: 34287942 PMCID: PMC9292251 SCOPUS ID: 2-s2.0-85112680925 07/22/2021

  • (Lee E, Grayson M, Klaver D, Fuller B, Dasgupta M, Steinberg J, Meurer J.) Prog Community Health Partnersh. 2022;16(2):193-203 PMID: 35662146 SCOPUS ID: 2-s2.0-85131700962 06/07/2022

  • (Lee E, Grayson M, Klaver D, Fuller B, Dasgupta M, Steinberg J, Meurer J.) Progress in community health partnerships : research, education, and action. 2022;16(2) PMID: 35662141 SCOPUS ID: 2-s2.0-85131702045 01/01/2022

  • (Steinberg JA.) J Allergy Clin Immunol. 2021 Dec;148(6):1473-1475 PMID: 34530018 SCOPUS ID: 2-s2.0-85116051600 09/17/2021

  • (Nelson A, Ashima, Singh, Dasgupta M, Simpson PM, Chiu A, Brousseau DC, Panepinto JA.) J Asthma. 2021 Oct;58(10):1298-1306 PMID: 32576073 PMCID: PMC7794085 SCOPUS ID: 2-s2.0-85087818963 06/25/2020

  • (Johnston DT, Busse PJ, Riedl MA, Maurer M, Anderson J, Nurse C, Inhaber N, Yu M, Banerji A, HELP Study Investigators.) Clin Exp Allergy. 2021 Oct;51(10):1391-1395 PMID: 34166549 PMCID: PMC9290609 SCOPUS ID: 2-s2.0-85113183008 06/25/2021

  • (Zembles T, Zhan Y, Chiu A, Brousseau DC, Vyles D.) Ann Allergy Asthma Immunol. 2021 Aug;127(2):259-260 PMID: 33940168 SCOPUS ID: 2-s2.0-85107440967 05/04/2021

  • (Lumry WR, Weller K, Magerl M, Banerji A, Longhurst HJ, Riedl MA, Lewis HB, Lu P, Devercelli G, Jain G, Maurer M, HELP Study Investigators.) Allergy. 2021 Apr;76(4):1188-1198 PMID: 33258114 PMCID: PMC8247292 SCOPUS ID: 2-s2.0-85098010100 12/02/2020

  • (Dressel A, Bell-Calvin J, Lee E, Hermanns L, Anderko L, Swaney V, Steinberg J, Hawkins M, Yeldell S.) Public Health Nurs. 2021 Mar;38(2):136-140 PMID: 33025643 SCOPUS ID: 2-s2.0-85092076160 10/08/2020

  • (Harrison TW, Chanez P, Menzella F, Canonica GW, Louis R, Cosio BG, Lugogo NL, Mohan A, Burden A, McDermott L, Garcia Gil E, Zangrilli JG, ANDHI study investigators.) Lancet Respir Med. 2021 Mar;9(3):260-274 PMID: 33357499 SCOPUS ID: 2-s2.0-85099581025 12/29/2020

  • (Mendez A, Pelz BJ.) Allergy Rhinol (Providence). 2021;12:21526567211041925 PMID: 34540335 PMCID: PMC8444276 09/21/2021

  • (Riedl MA, Maurer M, Bernstein JA, Banerji A, Longhurst HJ, Li HH, Lu P, Hao J, Juethner S, Lumry WR, HELP Investigators.) Allergy. 2020 Nov;75(11):2879-2887 PMID: 32452549 PMCID: PMC7689768 SCOPUS ID: 2-s2.0-85087498118 05/27/2020

  • (Vyles D, Chiu A, Routes J, Castells M, Phillips EJ, Visotcky A, Fraser R, Pezzin L, Brousseau DC.) J Allergy Clin Immunol Pract. 2020 Mar;8(3):1126-1128.e1 PMID: 31586667 PMCID: PMC7332348 SCOPUS ID: 2-s2.0-85073824604 10/07/2019

  • (Vyles D, Mistry RD, Heffner V, Drayna P, Chiu A, Visotcky A, Fraser R, Brousseau DC.) Acad Pediatr. 2019 Aug;19(6):684-690 PMID: 30703582 SCOPUS ID: 2-s2.0-85063442775 02/01/2019

  • (Gallagher JL, Rivera RD, Van Shepard K, Roushan T, Ahsan G, Ahamed SI, Chiu A, Jurken M, Simpson PM, Nugent M, Gobin KS, Wen CKF, Eldredge CE.) Telemed J E Health. 2019 Apr;25(4):319-325 PMID: 29969372 SCOPUS ID: 2-s2.0-85064382690 07/04/2018

  • (Busse WW, Bleecker ER, FitzGerald JM, Ferguson GT, Barker P, Sproule S, Olsson RF, Martin UJ, Goldman M, BORA study investigators.) Lancet Respir Med. 2019 Jan;7(1):46-59 PMID: 30416083 SCOPUS ID: 2-s2.0-85056170947 11/13/2018

  • (Pelz BJ, Wechsler JB, Amsden K, Johnson K, Singh AM, Wershil BK, Kagalwalla AF, Bryce PJ.) Clin Exp Allergy. 2016 Nov;46(11):1431-1440 PMID: 27388929 PMCID: PMC5085872 10/30/2016

  • (Pelz BJ, Bryce PJ.) Pediatr Clin North Am. 2015 Dec;62(6):1363-75 PMID: 26456437 10/13/2015

  • (Punwani D, Pelz B, Yu J, Arva NC, Schafernak K, Kondratowicz K, Makhija M, Puck JM.) J Clin Immunol. 2015 Feb;35(2):100-7 PMID: 25666293 PMCID: PMC4489527 02/11/2015

  • (Steinberg JA.) J Allergy Clin Immunol. 2015 Jan;135(1):131-2 PMID: 25445824 SCOPUS ID: 2-s2.0-84920603210 12/03/2014

  • (Miller EK, Avila PC, Khan YW, Word CR, Pelz BJ, Papadopoulos NG, Peebles RS Jr, Heymann PW, Microbes, Allergy, and Asthma Committee.) J Allergy Clin Immunol Pract. 2014;2(5):537-43 PMID: 25213046 PMCID: PMC4190166 09/13/2014

  • (Bauer CS, Chiu AM, Zafra HT, Gimenez LM, Nugent ML, Simpson PM, Vasudev M.) Ann Allergy Asthma Immunol. 2013 Jun;110(6):468-469.e9 PMID: 23706721 SCOPUS ID: 2-s2.0-84878216059 05/28/2013

  • (Gimenez LM, Zafra H.) Ann Allergy Asthma Immunol. 2011 Apr;106(4):267-74; quiz 275 PMID: 21457874 SCOPUS ID: 2-s2.0-79953305644 04/05/2011

  • (Gimenez LM, Zacharisen MC, Nordness ME.) Ann Allergy Asthma Immunol. 2003 Aug;91(2):141-7 PMID: 12952107 09/04/2003

  • (Erin Lee, Anne Dressel, Jean Bell-Calvin, Zhuping Garacci, Joshua Steinberg.) Journal of Allergy and Clinical Immunology. https://doi.org/10.1016/j.jaci.2019.12.684 02/01/2020

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