Kerns Laboratory

Location
MFRC 6009 (Lab)
MFRC 6010 (Office)

Research Areas

The Kerns lab studies inherited genetic predisposition to development of late toxicities resulting from cancer treatment. Approaches include genome-wide association studies (GWAS), analysis of circulating biomarkers, and analysis of gene expression and epigenetic changes using biospecimens from patients undergoing treatment for cancer. The long-term goal of our research is to develop predictive models for use in the clinic to better personalize cancer treatment and survivorship care. Research conducted in the lab also aims to uncover novel biologic pathways that might be targeted to prevent or mitigate the toxic effects of cancer treatment. Much of this work is done collaboratively, through research consortia, to facilitate large-scale clinical genomic studies. Dr. Kerns is a leader in the NCI-supported and a member of the NIH-funded .

Current Members

Sanchita Giri, MSc

Clinical Research Assistant II

sangiri@mcw.edu

Ayokunle Olowofela, MD, MS

Postdoctoral Researcher

aolowofela@mcw.edu

老澳门六合彩图库 Collaborators

William A. Hall, MD

Professor of Radiation Oncology and Surgery, School of Graduate Studies; Medical Director of Radiation Oncology, Froedtert & the 老澳门六合彩图库 Clinical Cancer Center

Clinical and research interests include pancreatic cancer, prostate cancer, MRI guided radiation therapy, renal cell carcinoma and rectal cancer.

Paul Auer, PhD

Cancer Center Scholar; Director, Biostatistics Shared Resource, Cancer Center; Professor, Data Science Institute, Biostatistics

pauer@mcw.edu

Manzur Rahman Farazi, PhD

Statistical Research Scientist II, Biostatistics

mfarazi@mcw.edu

Kerns Laboratory Funding

all

Current Funding

NIH/NCI R01CA291956
“Targeting angiotensin and inflammation to prevent radiotherapy-induced bladder toxicity”
(MPI: Marples, Kerns), 08/01/2024 – 07/31/2029

NIH/NCI R21CA280170
“The urinary microbiome and bladder toxicity after pelvic radiotherapy”
(MPI: Marples, Gill, Kerns), 08/01/2024 – 07/31/2026

NIH/NCI R01CA285801
“Multi-cohort validation of machine learning radiogenomic models (ML-RGx) to predict late toxicity in prostate cancer”
(MPI: Kerns, Hall, Oh), 07/01/2024 - 06/30/2029

NIH/NCI R01CA280115
“Clinical and pre-clinical investigation of extracellular vesicles as a mechanism of toxicity in the bladder of prostate cancer patients treated with radiotherapy”
(PI: Lee), 04/01/2024 – 03/31/2029

Completed Funding

NIH/NCI MP2PRT 22X016Q (subcontract to HHSN26100039)
“Evaluation of an inflammation polygenic risk score (iPRS) to predict cancer related cognitive impairment and fatigue in patients receiving chemotherapy for non-metastatic breast cancer in URCC0701 and URCC10055”
(PI: Kerns), 07/19/2022 – 12/31/2024

NIH/NCI UG1CA189961
“Biobank to Support Translational Research”
(MPIs: Janelsins, Kerns), 9/01/2021 – 8/31/2022

NIH/NCI K07CA187546
"Risk Prediction for Development of Adverse Effects Following Radiotherapy for Prostate Cancer”
(PI: Kerns), 9/18/2015 – 8/31/2021

Wilmot Cancer Institute’s Research Development Funding Program
“Elucidating the Role of the Renin-Angiotensin Pathway in Development of Hemorrhagic Radiation Cystitis”
(PIs: Kerns and Marples), 7/01/2020 – 6/30/2021

NIH/SBIR HHSN261201500043C
"Predictive Biomarkers of Adverse Reactions to Prostate Radiotherapy”
(PIs: Peterson-Roth, Kerns, Rosenstein), 9/1/2015 – 9/18/2020

DOD PC140371
"Genetic Modeling of Radiation Injury in Prostate Cancer Patients Treated With Radiotherapy”
(PIs: Rosenstein and Ostrer; UR site PI: Kerns), 9/1/2015 – 8/31/2018

(Kullo IJ, Conomos MP, Nelson SC, Adebamowo SN, Choudhury A, Conti D, Fullerton SM, Gogarten SM, Heavner B, Hornsby WE, Kenny EE, Khan A, Khera AV, Li Y, Martin I, Mercader JM, Ng M, Raffield LM, Reiner A, Rowley R, Schaid D, Stilp A, Wiley K, Wilson R, Witte JS, Natarajan P, Polygenic Risk Methods in Diverse Populations (PRIMED) Consortium.) Am J Hum Genet. 2024 Dec 05;111(12):2594-2606 PMID: 39561770 PMCID: PMC11639095 SCOPUS ID: 2-s2.0-85210411516 11/20/2024
(Rosenstein BS, Yamoah K, Bentzen SM, Kerns SL, McDonald JT, West CML, Vega A, Rattay T, Ricks-Santi LJ, Radiogenomics Consortium.) Int J Radiat Oncol Biol Phys. 2024 Nov 15;120(4):1107-1110 PMID: 39424580 SCOPUS ID: 2-s2.0-85206214409 10/19/2024
(Hall WA, Mathison AJ, DeVoe E, Tschannen M, Wendt-Andrae J, Straza M, Awan M, Puckett LL, Lawton CAF, Schultz C, Urrutia R, Kerns S, Torres-Roca JF, Li XA, Erickson B, Nevalainen MT, Zimmermann MT, Paulson E.) Int J Radiat Oncol Biol Phys. 2024 Oct 01;120(2):570-578 PMID: 38819340 SCOPUS ID: 2-s2.0-85194948255 05/31/2024
(Gehl CJ, Verhagen NB, Shaik TJ, Nimmer K, Yang X, Xing Y, Taylor BW, Nataliansyah MM, Kerns SL, Kothari AN.) J Am Coll Surg. 2024 Jun 26 PMID: 38920308 06/26/2024
(Sun Y, Tsai Y, Wood R, Shen B, Chen J, Zhou Z, Zeng G, Marples B, Kerns S, Chen Y.) Int J Radiat Oncol Biol Phys. 2024 May 01;119(1):251-260 PMID: 38008196 SCOPUS ID: 2-s2.0-85180584261 11/27/2023
(Liebenberg N, McWilliam A, Kerns SL, Marshall DC, West CM.) BMJ Oncol. 2024 Jan;3(1) PMID: 39524982 PMCID: PMC11256021 11/14/2024
(Cui W, Plett PA, Sharma GP, Kerns S, MacVittie TJ.) Front Public Health. 2024;12:1471228 PMID: 39234079 PMCID: PMC11372479 SCOPUS ID: 2-s2.0-85203343450 09/05/2024
(Wang A, Shen J, Rodriguez AA, Saunders EJ, Chen F, Janivara R, Darst BF, Sheng X, Xu Y, Chou AJ, Benlloch S, Dadaev T, Brook MN, Plym A, Sahimi A, Hoffman TJ, Takahashi A, Matsuda K, Momozawa Y, Fujita M, Laisk T, Figuerêdo J, Muir K, Ito S, Liu X, Biobank Japan Project, Uchio Y, Kubo M, Kamatani Y, Lophatananon A, Wan P, Andrews C, Lori A, Choudhury PP, Schleutker J, Tammela TLJ, Sipeky C, Auvinen A, Giles GG, Southey MC, MacInnis RJ, Cybulski C, Wokolorczyk D, Lubinski J, Rentsch CT, Cho K, Mcmahon BH, Neal DE, Donovan JL, Hamdy FC, Martin RM, Nordestgaard BG, Nielsen SF, Weischer M, Bojesen SE, Røder A, Stroomberg HV, Batra J, Chambers S, Horvath L, Clements JA, Tilly W, Risbridger GP, Gronberg H, Aly M, Szulkin R, Eklund M, Nordstrom T, Pashayan N, Dunning AM, Ghoussaini M, Travis RC, Key TJ, Riboli E, Park JY, Sellers TA, Lin HY, Albanes D, Weinstein S, Cook MB, Mucci LA, Giovannucci E, Lindstrom S, Kraft P, Hunter DJ, Penney KL, Turman C, Tangen CM, Goodman PJ, Thompson IM Jr, Hamilton RJ, Fleshner NE, Finelli A, Parent MÉ, Stanford JL, Ostrander EA, Koutros S, Beane Freeman LE, Stampfer M, Wolk A, Håkansson N, Andriole GL, Hoover RN, Machiela MJ, Sørensen KD, Borre M, Blot WJ, Zheng W, Yeboah ED, Mensah JE, Lu YJ, Zhang HW, Feng N, Mao X, Wu Y, Zhao SC, Sun Z, Thibodeau SN, McDonnell SK, Schaid DJ, West CML, Barnett G, Maier C, Schnoeller T, Luedeke M, Kibel AS, Drake BF, Cussenot O, Cancel-Tassin G, Menegaux F, Truong T, Koudou YA, John EM, Grindedal EM, Maehle L, Khaw KT, Ingles SA, Stern MC, Vega A, Gómez-Caamaño A, Fachal L, Rosenstein BS, Kerns SL, Ostrer H, Teixeira MR, Paulo P, Brandão A, Watya S, Lubwama A, Bensen JT, Butler EN, Mohler JL, Taylor JA, Kogevinas M, Dierssen-Sotos T, Castaño-Vinyals G, Cannon-Albright L, Teerlink CC, Huff CD, Pilie P, Yu Y, Bohlender RJ, Gu J, Strom SS, Multigner L, Blanchet P, Brureau L, Kaneva R, Slavov C, Mitev V, Leach RJ, Brenner H, Chen X, Holleczek B, Schöttker B, Klein EA, Hsing AW, Kittles RA, Murphy AB, Logothetis CJ, Kim J, Neuhausen SL, Steele L, Ding YC, Isaacs WB, Nemesure B, Hennis AJM, Carpten J, Pandha H, Michael A, De Ruyck K, De Meerleer G, Ost P, Xu J, Razack A, Lim J, Teo SH, Newcomb LF, Lin DW, Fowke JH, Neslund-Dudas CM, Rybicki BA, Gamulin M, Lessel D, Kulis T, Usmani N, Abraham A, Singhal S, Parliament M, Claessens F, Joniau S, Van den Broeck T, Gago-Dominguez M, Castelao JE, Martinez ME, Larkin S, Townsend PA, Aukim-Hastie C, Bush WS, Aldrich MC, Crawford DC, Srivastava S, Cullen J, Petrovics G, Casey G, Wang Y, Tettey Y, Lachance J, Tang W, Biritwum RB, Adjei AA, Tay E, Truelove A, Niwa S, Yamoah K, Govindasami K, Chokkalingam AP, Keaton JM, Hellwege JN, Clark PE, Jalloh M, Gueye SM, Niang L, Ogunbiyi O, Shittu O, Amodu O, Adebiyi AO, Aisuodionoe-Shadrach OI, Ajibola HO, Jamda MA, Oluwole OP, Nwegbu M, Adusei B, Mante S, Darkwa-Abrahams A, Diop H, Gundell SM, Roobol MJ, Jenster G, van Schaik RHN, Hu JJ, Sanderson M, Kachuri L, Varma R, McKean-Cowdin R, Torres M, Preuss MH, Loos RJF, Zawistowski M, Zöllner S, Lu Z, Van Den Eeden SK, Easton DF, Ambs S, Edwards TL, Mägi R, Rebbeck TR, Fritsche L, Chanock SJ, Berndt SI, Wiklund F, Nakagawa H, Witte JS, Gaziano JM, Justice AC, Mancuso N, Terao C, Eeles RA, Kote-Jarai Z, Madduri RK, Conti DV, Haiman CA.) Nat Genet. 2023 Dec;55(12):2065-2074 PMID: 37945903 PMCID: PMC10841479 SCOPUS ID: 2-s2.0-85176259299 11/10/2023

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